Twisted Italian Meatballs
Total Time
Prep: 30 min. Cook: 6-1/4 hours
Yield
5 servings
Twisted Italian meatballs earn their name with surprises at every turn. With four kinds of meat, a gooey mozzarella center, and a bold sauce made from marinara and chunky salsa, these slow-cooked meatballs are a flavor-packed twist on a classic.
Ingredients
- 3 ounces prosciutto, finely chopped
- 8 slices peppered hard salami (about 1 ounce total), finely chopped
- 1/4 cup finely chopped onion
- 1 garlic clove, minced
- 2 large eggs, lightly beaten
- 1/2 teaspoon salt
- 1 teaspoon Greek seasoning
- 10 fresh basil leaves, finely chopped
- 1-1/2 cups panko bread crumbs
- 1/3 cup grated Parmesan cheese
- 1/2 pound ground beef
- 1/2 pound bulk Italian sausage
- 15 fresh mozzarella cheese pearls
- 1 jar (24 ounces) marinara sauce
- 1 jar (16 ounces) chunky salsa
- 1/2 cup shredded mozzarella cheese
- 1 pound cooked pappardelle pasta
Directions
- In a large bowl, combine the first 10 ingredients. Crumble beef and sausage over mixture; mix lightly but thoroughly. Divide meat mixture into 15 portions; shape each around a mozzarella pearl.
- Place half the marinara and salsa in the bottom of a 6-qt. slow cooker. Place meatballs into sauce. Pour remaining marinara and salsa over top.
- Cook, covered, on low until a thermometer inserted in the meat reads 160°, about 6 hours. Sprinkle mozzarella over meatballs; cover and cook until cheese is melted, about 15 minutes longer.
- Serve with cooked pappardelle pasta. Sprinkle with additional grated parmesan if desired.
Nutrition Facts
1 serving: 508 calories, 29g fat (11g saturated fat), 169mg cholesterol, 2522mg sodium, 44g carbohydrate (11g sugars, 3g fiber), 31g protein.
I love making meatballs, and I've been told I make as good a meatball as any Italian nonna. I hide a little fresh mozzarella ball in the center of each one, which melts as they cook, for an irresistible final touch. —Becky Ellis, Roanoke, Virginia
Recipe Creator
© 2026 RDA Enthusiast Brands, LLC